Harmony Prenatal Testing

The Harmony prenatal test is a screening test. It can tell if there is a high or low chance for the common chromosomal conditions: Down syndrome (trisomy 21), trisomy 18 and trisomy 13. It can also tell the chance of having an extra or missing sex chromosome (X or Y), and the sex of your baby.

NIPT is a blood test that looks at fetal DNA found in the mother’s bloodstream. This screening test helps determine if your baby is at increased risk for a number of chromosomal abnormalities, including Down syndrome (trisomy 21), Edwards syndrome (trisomy 18), Patau syndrome (trisomy 13) and sex chromosome abnormalities. NIPT can also assess the likelihood your baby has a condition linked to a few selected microdeletions.

There are many different types of microdeletions, a group of disorders caused by missing a small amount of genetic information. The most common microdeletion is 22q11.2 deletion syndrome. It affects as many as 1 in 1,000 to 1 in 2,500 pregnancies, making it almost as common as Down syndrome.1 Early detection of 22q11.2 deletion syndrome can help ensure your baby receives any necessary treatment from the moment the baby is born.

There are three potential Harmony test outcomes:

High-probability result. This means there is a higher probability than expected for a chromosomal condition in the pregnancy. Additional testing during the pregnancy and/or evaluation after delivery may be recommended.

Low-probability result. This means there is a low probability for the chromosomal conditions that were screened for in the pregnancy. Routine prenatal management would continue as usual.

No result is able to be obtained. In a small percentage of cases, a Harmony result is unable to be obtained. In this instance, your provider may discuss options for an additional blood sample to be drawn or offer other screening or diagnostic testing options.

  • A blood sample is taken at 10 weeks or later in pregnancy
  • Your sample is sent to the laboratory, where it is analyzed.
  • Your results are sent to your healthcare provider within 3-5 days from sample receipt.